Thalidomide-4-Br

Name: Thalidomide-4-Br
Brand: ChemScene
Availability: InStock
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CAS No. 2093536-12-8
Cat. No. CS-0096700
Purity≥95%
MDL No.MFCD31730866

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 2093536-12-8

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General Information

CAS No. 2093536-12-8
Cat. No. CS-0096700
Purity ≥95%
MDL No. MFCD31730866
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₉BrN₂O₄
Molecular Weight 337.13
Synonym(s) None
SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3Br)=O

Description

Thalidomide-4-Br features a brominated derivative of thalidomide at the 4-position, enabling selective functionalization for targeted drug discovery. This modification enhances metabolic stability and facilitates conjugation in covalent inhibitor design, offering a valuable scaffold for developing novel therapeutics with improved pharmacokinetic profiles.

Application

Thalidomide-4-Br serves as a versatile brominated derivative of thalidomide, enabling site-specific functionalization in medicinal chemistry campaigns. The 4-bromo substituent provides a reliable handle for palladium-catalyzed cross-coupling reactions, facilitating the construction of diverse analogs for target engagement studies. Its bench-stable nature and compatibility with standard synthetic workflows make it a practical building block for exploring structure-activity relationships within the immunomodulatory imide scaffold.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 83.55
LogP 0.8346
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

General Reagents Organic General Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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Thalidomide-4-Br

CAS No. 2093536-12-8

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