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CS-W001157 4
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6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylic acid

  • CAS No. 2089381-00-8

  • Cat. No. CS-0138354
  • Purity≥98%
  • MDL No.MFCD30529017

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylic acid|CS-0138354

Structure of 2089381-00-8

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General Information

  • CAS No. 2089381-00-8
  • Cat. No. CS-0138354
  • Purity ≥98%
  • MDL No. MFCD30529017
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrN₂O₃
  • Molecular Weight 271.07
  • Synonym(s) None
  • SMILES O=C(C1=C2C(OC)=CC(Br)=CN2N=C1)O

Description

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylic acid features a fused heterocyclic core bearing bromo and methoxy substituents at electron-rich positions, enabling direct functionalization in cross-coupling reactions. The carboxylic acid group provides a handle for amide bond formation or salt generation, enhancing solubility and bioavailability. This scaffold exhibits stability under standard reaction conditions, facilitating use in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carboxylic acid serves as a versatile building block for the synthesis of biologically active heterocycles. Its bromo and carboxylic acid functionalities enable palladium-catalyzed cross-coupling and derivatization reactions, while the methoxy group provides orthogonal reactivity. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.83
  • LogP   1.8036
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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