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CS-W001157 4
Total: USD 88.00

PDK1-IN-1

  • CAS No. 1207836-10-9

  • Cat. No. CS-0081748
  • Purity≥97%
  • MDL No.MFCD27937916

*For research and further manufacturing use only, not for direct human use.

PDK1-IN-1|CS-0081748

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General Information

  • CAS No. 1207836-10-9
  • Cat. No. CS-0081748
  • Purity ≥97%
  • MDL No. MFCD27937916
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆BrN₃O
  • Molecular Weight 252.07
  • Synonym(s) None
  • SMILES BrC1=CN2C(C(OC)=C1)=C(C=N2)C#N

Description

PDK1-IN-1 is a potent, selective inhibitor of PDK1, targeting the pyruvate dehydrogenase kinase isoform 1. This compound features a unique scaffold that enables effective engagement with the ATP-binding site, offering strong inhibition under physiological conditions. Designed for cellular and biochemical studies, it provides high specificity in metabolic pathway interrogation.

Application

PDK1-IN-1 serves as a well-characterized, cell-permeable inhibitor of the PDK1 kinase, enabling targeted investigation of metabolic regulation in cancer and metabolic disorders. Its robust stability and defined pharmacological profile facilitate reliable use in cellular assays and mechanistic studies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.32
  • LogP   1.97708
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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