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CS-W001157 4
Total: USD 88.00

1-(tert-Butoxycarbonyl)indoline-6-carboxylic acid

  • CAS No. 208772-41-2

  • Cat. No. CS-0073454
  • Purity≥97%
  • MDL No.MFCD09878909

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)indoline-6-carboxylic acid|CS-0073454

Structure of 208772-41-2

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General Information

  • CAS No. 208772-41-2
  • Cat. No. CS-0073454
  • Purity ≥97%
  • MDL No. MFCD09878909
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇NO₄
  • Molecular Weight None
  • Synonym(s) 2,3-Dihydro-indole-1,6-dicarboxylic acid 1-tert-butyl ester
  • SMILES O=C(OC(C)(C)C)N1C2=CC(C(O)=O)=CC=C2CC1

Description

This protected indoline derivative features a tert-butoxycarbonyl group at the nitrogen and a carboxylic acid at the 6-position, enabling selective functionalization in peptide coupling and heterocyclic synthesis. The Boc protection ensures stability under standard reaction conditions while allowing facile deprotection with mild acid.

Application

1-(tert-Butoxycarbonyl)indoline-6-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to indoline-based scaffolds. The tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. It functions effectively in standard coupling reactions and supports the synthesis of complex heterocycles relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.6824
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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