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5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid

  • CAS No. 1209492-73-8

  • Cat. No. CS-B1016
  • Purity≥95%
  • MDL No.MFCD16987654

*For research and further manufacturing use only, not for direct human use.

5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid|CS-B1016

Structure of 1209492-73-8

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General Information

  • CAS No. 1209492-73-8
  • Cat. No. CS-B1016
  • Purity ≥95%
  • MDL No. MFCD16987654
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇N₃O₄
  • Molecular Weight 267.28
  • Synonym(s) Pyrazolo[1,5-a]pyrazine-2,5(4H)-dicarboxylic acid, 6,7-dihydro-,5-(1,1-dimethylethyl) ester
  • SMILES O=C(C1=NN2C(CN(C(OC(C)(C)C)=O)CC2)=C1)O

Description

This tetrahydropyrazolo[1,5-a]pyrazine derivative features a tert-butoxycarbonyl-protected amine and a carboxylic acid group, enabling direct incorporation into peptide mimetics and heterocyclic scaffolds. The protected nitrogen and polar functionalities provide enhanced solubility and stability during synthetic manipulations.

Application

5-(tert-Butoxycarbonyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid serves as a versatile building block for the synthesis of tetrahydropyrazolo[1,5-a]pyrazine scaffolds. Its tert-butyl ester group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The carboxylic acid functionality enables direct coupling reactions and further functionalization, supporting diverse transformations in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   84.66
  • LogP   1.332
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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