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CS-W001157 4
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2-Bromo-3-fluoropyrazine

  • CAS No. 206278-27-5

  • Cat. No. CS-0059874
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-3-fluoropyrazine|CS-0059874

Structure of 206278-27-5

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General Information

  • CAS No. 206278-27-5
  • Cat. No. CS-0059874
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrFN₂
  • Molecular Weight 176.97
  • Synonym(s) None
  • SMILES C=1(C(=NC=CN1)F)Br

Description

2-Bromo-3-fluoropyrazine is a halogenated pyrazine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromine at the 2-position enables palladium-catalyzed coupling, while the fluorine at the 3-position offers orthogonal reactivity or enhanced electronic modulation. This dual-heteroatom pattern supports precise molecular diversification in medicinal chemistry and materials synthesis.

Application

2-Bromo-3-fluoropyrazine serves as a versatile building block in the synthesis of functionalized pyrazine scaffolds, enabling palladium-catalyzed cross-coupling reactions and nucleophilic substitution processes. Its complementary halogenation pattern facilitates sequential functionalization, while its bench-stable nature supports reliable handling in multi-step synthetic sequences for medicinal chemistry and agrochemical applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.3782
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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