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CS-W001157 4
Total: USD 88.00

Mal-amido-PEG3-acid

  • CAS No. 2055353-75-6

  • Cat. No. CS-0167709
  • Molecule weight372.37
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Mal-amido-PEG3-acid|CS-0167709

Structure of 2055353-75-6

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General Information

  • CAS No. 2055353-75-6
  • Cat. No. CS-0167709
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₄N₂O₈
  • Molecular Weight 372.37
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O

Description

Mal-amido-PEG3-acid is a bifunctional linker featuring a maleimide group conjugated to a PEG3 spacer terminated with a carboxylic acid. This design enables site-specific bioconjugation via thiol-Michael addition, while the hydrophilic PEG chain enhances solubility and reduces non-specific binding. The terminal carboxyl group facilitates further coupling reactions under standard activation conditions.

Application

Mal-amido-PEG3-acid serves as a versatile, water-soluble bifunctional linker for conjugation workflows. The maleimide group enables site-specific thiol-Click coupling under physiological conditions, while the PEG3 spacer provides enhanced solubility and reduced non-specific binding. The terminal carboxylic acid facilitates amide coupling with primary amines, enabling efficient construction of dual-functional bioconjugates. Bench-stable and compatible with standard purification methods, it supports robust synthesis of antibody-drug conjugates, peptide-protein hybrids, and targeted delivery systems.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   131.47
  • LogP   -1.0578
  • H_Acceptors   7
  • H_Donors   2
  • Rotatable_Bonds   15

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