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CS-W001157 4
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Mal-amido-PEG4-acid

  • CAS No. 1263045-16-4

  • Cat. No. CS-0107665
  • Purity≥95%
  • MDL No.MFCD13184954

*For research and further manufacturing use only, not for direct human use.

Mal-amido-PEG4-acid|CS-0107665

Structure of 1263045-16-4

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General Information

  • CAS No. 1263045-16-4
  • Cat. No. CS-0107665
  • Purity ≥95%
  • MDL No. MFCD13184954
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₈N₂O₉
  • Molecular Weight 416.42
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O

Description

Mal-amido-PEG4-acid is a bifunctional linker featuring a maleimide group conjugated to a PEG4 spacer terminating in a carboxylic acid. This design enables site-specific bioconjugation via thiol-Michael addition, while the terminal acid facilitates further coupling reactions. The PEG4 segment provides enhanced solubility and reduced aggregation in aqueous environments.

Application

Mal-amido-PEG4-acid serves as a versatile bifunctional linker for bioconjugation, combining the reactive maleimide group with a stable PEG4 spacer and carboxylic acid terminus. It enables site-specific conjugation to thiol-containing biomolecules while providing enhanced solubility and reduced non-specific binding. The PEG4 chain minimizes steric hindrance, facilitating efficient labeling in complex biological environments. Ideal for antibody-drug conjugate (ADC) synthesis and peptide modification workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   140.7
  • LogP   -1.0412
  • H_Acceptors   8
  • H_Donors   2
  • Rotatable_Bonds   18

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