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Mal-PEG8-NHS ester

  • CAS No. 2055033-05-9

  • Cat. No. CS-0107989
  • Molecule weight618.63
  • Purity≥95%
  • MDL No.MFCD26127784

*For research and further manufacturing use only, not for direct human use.

Mal-PEG8-NHS ester|CS-0107989

Structure of 2055033-05-9

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General Information

  • CAS No. 2055033-05-9
  • Cat. No. CS-0107989
  • Purity ≥95%
  • MDL No. MFCD26127784
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₄₂N₂O₁₄
  • Molecular Weight 618.63
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN2C(C=CC2=O)=O

Description

Mal-PEG8-NHS ester is a bifunctional crosslinker featuring a maleimide group and a reactive NHS ester, separated by an 8-unit PEG spacer. This design enables efficient conjugation to thiol-containing biomolecules and amine-functionalized surfaces under physiological conditions. The hydrophilic PEG chain minimizes non-specific binding and enhances solubility in aqueous environments.

Application

Mal-PEG8-NHS ester serves as a versatile bifunctional linker for site-specific conjugation, combining the reactive maleimide group with a hydrophilic PEG8 spacer and an NHS ester for amine coupling. It enables efficient, orthogonal bioconjugation in aqueous conditions, offering enhanced stability and reduced aggregation compared to shorter PEG chains. Ideal for antibody-drug conjugate (ADC) synthesis and protein labeling, it facilitates reliable conjugation with minimal side reactions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   174.9
  • LogP   -0.9585
  • H_Acceptors   14
  • H_Donors   0
  • Rotatable_Bonds   28

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