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N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine

  • CAS No. 204580-28-9

  • Cat. No. CS-0154942
  • Purity≥96%
  • MDL No.MFCD20662141

*For research and further manufacturing use only, not for direct human use.

N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine|CS-0154942

Structure of 204580-28-9

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General Information

  • CAS No. 204580-28-9
  • Cat. No. CS-0154942
  • Purity ≥96%
  • MDL No. MFCD20662141
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₂₃NOSi
  • Molecular Weight 189.37
  • Synonym(s) None
  • SMILES CC(C)(C)[Si](C)(C)OCCNC

Description

N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine features a silyl-protected hydroxyl group paired with a primary amine, enabling orthogonal functionalization in complex synthesis. This bench-stable derivative facilitates selective deprotection and coupling workflows, particularly in oligonucleotide and peptide conjugation strategies where stability and regioselective reactivity are critical.

Application

N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine serves as a versatile silyl-protected amine building block, enabling selective functionalization in complex molecule synthesis. The tert-butyldimethylsilyl (TBS) group provides robust protection under standard conditions, with high stability toward nucleophiles and mild acidic/basic environments. It facilitates orthogonal handling in multi-step sequences, allowing controlled deprotection via fluoride sources. Its methylamino functionality supports direct coupling or derivatization, making it ideal for peptide analogs, agrochemical intermediates, and pharmaceutical scaffolds requiring reliable protection strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.2276
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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