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CS-W001157 4
Total: USD 88.00

(4-(Trifluoromethyl)thiazol-2-yl)methanol

  • CAS No. 204319-69-7

  • Cat. No. CS-0042535
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-(Trifluoromethyl)thiazol-2-yl)methanol|CS-0042535

Structure of 204319-69-7

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General Information

  • CAS No. 204319-69-7
  • Cat. No. CS-0042535
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₃NOS
  • Molecular Weight 183.15
  • Synonym(s) [4-(trifluoromethyl)-1,3-thiazol-2-yl]methanol
  • SMILES OCC1=NC(C(F)(F)F)=CS1

Description

This trifluoromethylthiazole derivative features a reactive hydroxymethyl group positioned at the 4-position of a stable thiazole scaffold. The electron-withdrawing trifluoromethyl substituent enhances the electrophilicity of the adjacent carbon, enabling efficient coupling reactions in synthetic workflows. Designed for use in medicinal chemistry and functional materials synthesis, this compound offers improved solubility and stability under standard bench conditions.

Application

(4-(Trifluoromethyl)thiazol-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling the efficient construction of thiazole-containing scaffolds via standard functional group transformations. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the pendant alcohol facilitates derivatization through esterification, etherification, or oxidation to aldehyde. The compound exhibits excellent bench stability and compatibility with common reaction conditions, making it a practical choice for modular synthesis of bioactive molecules and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.6542
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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