Fmoc-D-Phe(4-Me)-OH

Name: Fmoc-D-Phe(4-Me)-OH
Brand: ChemScene
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CAS No. 204260-38-8
Cat. No. CS-0153092
Purity≥98%
MDL No.MFCD00270196

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 204260-38-8
Cat. No. CS-0153092
Purity ≥98%
MDL No. MFCD00270196
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₃NO₄
Molecular Weight 401.45
Synonym(s) Fmoc-4-methyl-D-phenylalanine
SMILES CC1=CC=C(C[C@@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)C(O)=O)C=C1

Description

Fmoc-D-Phe(4-Me)-OH features a fluorophore-masked D-phenylalanine derivative with a para-methyl substituent, enabling efficient incorporation into peptide chains. The electron-donating methyl group enhances stability and modulates backbone conformation during solid-phase synthesis. This bench-stable building block facilitates the installation of D-configured aromatic residues in bioactive peptide sequences.

Application

Fmoc-D-Phe(4-Me)-OH serves as a key building block in peptide synthesis, enabling the incorporation of D-phenylalanine with a para-methyl substituent. The Fmoc group provides orthogonal protection for amine functionality, facilitating efficient stepwise chain elongation. The 4-methylphenyl side chain enhances hydrophobicity and steric bulk, offering favorable properties for peptide stability and receptor interaction. This derivative exhibits excellent bench stability, clean coupling efficiency, and compatibility with standard purification methods, making it ideal for medicinal chemistry and peptide library development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 4.52942
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Phe(4-Me)-OH

CAS No. 204260-38-8

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