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CS-W001157 4
Total: USD 88.00

3-(Trifluoromethoxy)benzeneacetic acid

  • CAS No. 203302-97-0

  • Cat. No. CS-0020102
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD00082480

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethoxy)benzeneacetic acid|CS-0020102

Structure of 203302-97-0

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General Information

  • CAS No. 203302-97-0
  • Cat. No. CS-0020102
  • Purity ≥98%
  • MDL No. MFCD00082480
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O₃
  • Molecular Weight None
  • Synonym(s) 2-[3-(Trifluoromethoxy)phenyl]acetic acid; [3-(Trifluoromethoxy)phenyl]acetic acid; Trifluoromethoxyphenylaceticacid
  • SMILES O=C(O)CC1=CC=CC(OC(F)(F)F)=C1

Description

3-(Trifluoromethoxy)benzeneacetic acid features a trifluoromethoxy group conjugated to a benzene ring, delivering enhanced lipophilicity and metabolic stability. The carboxylic acid functionality enables direct coupling in peptide synthesis or bioconjugation workflows. This compound serves as a key building block for pharmaceutical intermediates and functionalized materials.

Application

3-(Trifluoromethoxy)benzeneacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard coupling reactions. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the benzoic acid side chain facilitates derivatization via esterification, amidation, or amide coupling. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for high-throughput screening and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.2123
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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