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CS-W001157 4
Total: USD 88.00

3-(Trifluoromethoxy)benzeneacetic acid

  • CAS No. 203302-97-0

  • Cat. No. CS-0020102
  • Purity≥98%
  • MDL No.MFCD00082480
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(Trifluoromethoxy)benzeneacetic acid|CS-0020102

Structure of 203302-97-0

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Description

3-(Trifluoromethoxy)benzeneacetic acid features a trifluoromethoxy group conjugated to a benzene ring, delivering enhanced lipophilicity and metabolic stability. The carboxylic acid functionality enables direct coupling in peptide synthesis or bioconjugation workflows. This compound serves as a key building block for pharmaceutical intermediates and functionalized materials.

Application

3-(Trifluoromethoxy)benzeneacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard coupling reactions. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the benzoic acid side chain facilitates derivatization via esterification, amidation, or amide coupling. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for high-throughput screening and API intermediate development.

General Information

  • CAS No. 203302-97-0
  • Cat. No. CS-0020102
  • Purity ≥98%
  • MDL No. MFCD00082480
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O₃
  • Molecular Weight None
  • Synonym(s) 2-[3-(Trifluoromethoxy)phenyl]acetic acid; [3-(Trifluoromethoxy)phenyl]acetic acid; Trifluoromethoxyphenylaceticacid
  • SMILES O=C(O)CC1=CC=CC(OC(F)(F)F)=C1

Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.2123
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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