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CS-W001157 4
Total: USD 88.00

(E)-3,4,5-Trimethoxycinnamic acid

  • CAS No. 20329-98-0

  • Cat. No. CS-0042365
  • Purity≥98%
  • MDL No.MFCD00004388

*For research and further manufacturing use only, not for direct human use.

(E)-3,4,5-Trimethoxycinnamic acid|CS-0042365

Structure of 20329-98-0

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General Information

  • CAS No. 20329-98-0
  • Cat. No. CS-0042365
  • Purity ≥98%
  • MDL No. MFCD00004388
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄O₅
  • Molecular Weight None
  • Synonym(s) TMCA
  • SMILES O=C(O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1

Description

This (E)-configured cinnamic acid derivative features three methoxy groups positioned at the 3,4,5-aryl ring sites, delivering enhanced electron density and solubility in organic solvents. The conjugated system enables efficient integration into photoreactive or bioconjugation scaffolds. Its bench-stable nature supports reliable use in synthetic workflows requiring precise functional group presentation.

Application

(E)-3,4,5-Trimethoxycinnamic acid serves as a versatile building block in medicinal chemistry and natural product synthesis, offering a stable, bench-ready platform for structural diversification. Its conjugated enone system enables reliable Michael addition and palladium-catalyzed coupling reactions, while the three methoxy groups provide enhanced solubility and metabolic stability. The compound functions effectively in the construction of bioactive heterocycles and scaffold elaboration under standard reaction conditions.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.99
  • LogP   1.8102
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   5

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