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CS-W001157 4
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2-Methoxypyridin-3-amine

  • CAS No. 20265-38-7

  • Cat. No. CS-W008209
  • Purity≥98%
  • MDL No.MFCD00833386

*For research and further manufacturing use only, not for direct human use.

2-Methoxypyridin-3-amine|CS-W008209

Structure of 20265-38-7

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General Information

  • CAS No. 20265-38-7
  • Cat. No. CS-W008209
  • Purity ≥98%
  • MDL No. MFCD00833386
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight 124.14
  • Synonym(s) 3-AMINO-2-METHOXYPYRIDINE
  • SMILES NC1=CC=CN=C1OC

Description

2-Methoxypyridin-3-amine features a pyridine ring functionalized with a methoxy group at the 2-position and an amino group at the 3-position, delivering enhanced solubility and electron-donating character. This combination enables efficient coupling in transition-metal-catalyzed reactions and facilitates incorporation into bioactive scaffolds. The compound exhibits bench-stable handling properties and serves as a key building block for pharmaceutical intermediates and ligand development.

Application

2-Methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds. Its ortho-methoxy and amino functionalities offer complementary reactivity for cross-coupling, electrophilic substitution, and derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting bioactive heterocycles.

Synthesis

  • Route1

    References

    • Dolle, Valerie; Nguyen, Chi Hung; Bisagni, Emile Tetrahedron, 1997 , vol. 53, # 37 p. 12505 - 12524
  • Route2

    References

    • Chemische Berichte, , vol. 68, p. 315,321
  • Route3
    • 2-Methoxynicotinamide|CS-0725829
      7145-28-0
    • ~%
    • In-stock
      2-Methoxypyridin-3-amine|CS-W008209
      20265-38-7

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 24 p. 6265 - 6273

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.6724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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