2-Chloro-5-methoxybenzenesulfonyl chloride

Name: 2-Chloro-5-methoxybenzenesulfonyl chloride
Brand: ChemScene
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CAS No. 201935-41-3
Cat. No. CS-0092662
Purity≥95%
MDL No.MFCD12026184

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Chloro-5-methoxybenzenesulfonyl chloride|CS-0092662

Structure of 201935-41-3

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General Information

CAS No. 201935-41-3
Cat. No. CS-0092662
Purity ≥95%
MDL No. MFCD12026184
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆Cl₂O₃S
Molecular Weight 241.09
Synonym(s) 2-chloro-5-methoxyphenylsulfonyl chloride
SMILES O=S(C1=CC(OC)=CC=C1Cl)(Cl)=O

Description

2-Chloro-5-methoxybenzenesulfonyl chloride features a sulfonyl chloride group flanked by electron-donating methoxy and electron-withdrawing chloro substituents, enabling selective acylation in synthetic workflows. This bench-stable reagent integrates readily into aromatic sulfonation sequences and serves as a key intermediate for functionalized arylsulfonyl derivatives in pharmaceutical development.

Application

2-Chloro-5-methoxybenzenesulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of sulfonamide functionalities under mild conditions. Its ortho-chloro and meta-methoxy substituents enhance reactivity while maintaining bench stability, enabling clean coupling with amines and heterocyclic nitrogen nucleophiles. The compound facilitates rapid access to sulfonamide-containing building blocks relevant to medicinal chemistry and agrochemical research, offering predictable regiochemistry and straightforward purification via crystallization or chromatography.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 43.37
LogP 2.2761
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-5-methoxybenzenesulfonyl chloride

CAS No. 201935-41-3

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