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CS-W001157 4
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1-(2-Naphthyl)methanamine

  • CAS No. 2018-90-8

  • Cat. No. CS-W002778
  • Purity≥96%
  • MDL No.MFCD01529867

*For research and further manufacturing use only, not for direct human use.

1-(2-Naphthyl)methanamine|CS-W002778

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General Information

  • CAS No. 2018-90-8
  • Cat. No. CS-W002778
  • Purity ≥96%
  • MDL No. MFCD01529867
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁N
  • Molecular Weight 157.21
  • Synonym(s) 2-Naphthalenemethanamine
  • SMILES NCc1ccc2c(c1)cccc2

Description

1-(2-Naphthyl)methanamine is a bench-stable, electron-rich arylamine featuring a naphthalene moiety linked via a methylene bridge. This structure enables direct incorporation into heterocyclic scaffolds and facilitates coupling reactions in synthetic organic chemistry workflows.

Application

1-(2-Naphthyl)methanamine serves as a versatile arylalkyl amine building block, enabling efficient construction of biologically relevant scaffolds. Its bench-stable nature and compatibility with standard functional group transformations facilitate straightforward incorporation into pharmaceutical intermediates. The molecule functions effectively in reductive amination protocols and serves as a key precursor for heterocyclic systems and targeted drug candidates.

Synthesis

  • Route1

    References

    • Johansson, Henrik; Cailly, Thomas; Thomsen, Alex Rojas Bie; Braeuner-Osborne, Hans; Pedersen, Daniel Sejer Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1383 - 1387
  • Route2

    References

    • SENTINEL ONCOLOGY LIMITED; BOYLE, Robert, George; WALKER, David, Winter Patent: WO2010/136755 A1, 2010 ; Location in patent: Page/Page column 65; 66 ; WO 2010/136755 A1
  • Route3
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      247570-26-9
    • ~79%
    • In-stock
      1-(2-Naphthyl)methanamine|CS-W002778
      2018-90-8

    References

    • Luethy, Monique; Schenk, Kurt; Renaud, Philippe Chemistry - A European Journal, 2010 , vol. 16, # 33 p. 10171 - 10177

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.2985
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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