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CS-W001157 4
Total: USD 88.00

2-Naphthamide

  • CAS No. 2243-82-5

  • Cat. No. CS-W021732
  • Purity≥97%
  • MDL No.MFCD00016812

*For research and further manufacturing use only, not for direct human use.

2-Naphthamide|CS-W021732

Structure of 2243-82-5

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General Information

  • CAS No. 2243-82-5
  • Cat. No. CS-W021732
  • Purity ≥97%
  • MDL No. MFCD00016812
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO
  • Molecular Weight None
  • Synonym(s) Naphthalene-2-carboxamide
  • SMILES O=C(N)C1=CC=C2C=CC=CC2=C1

Description

2-Naphthamide features a rigid, planar naphthalene core with an amide functional group at the 2-position, enabling strong π-stacking and hydrogen bonding. This structural motif enhances solubility in polar organic solvents and provides stability under standard bench conditions, making it suitable for use in pharmaceutical intermediates, polymer synthesis, and as a building block in heterocyclic chemistry.

Application

2-Naphthamide serves as a versatile building block in synthetic organic chemistry, enabling the construction of biologically relevant heterocycles and pharmaceutical intermediates. Its amide functionality exhibits robust stability under standard reaction conditions, tolerates a range of functional groups, and participates reliably in electrophilic substitution, coupling reactions, and cyclization processes. The naphthalene core provides extended π-conjugation and rigidity, enhancing its utility in scaffold development for medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Angewandte Chemie - International Edition, , vol. 47, # 19 p. 3607 - 3609
  • Route2

    References

    • Advanced Synthesis and Catalysis, , vol. 352, # 2-3 p. 288 - 292
  • Route3

    References

    • US2007/105907 A1, ; Page/Page column 10 ; US 20070105907 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.9387
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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