Fmoc-Orn(Fmoc)-OH

Name: Fmoc-Orn(Fmoc)-OH
Brand: ChemScene
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CAS No. 201046-59-5
Cat. No. CS-0149830
Purity≥98%
MDL No.MFCD00153362

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 201046-59-5
Cat. No. CS-0149830
Purity ≥98%
MDL No. MFCD00153362
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₅H₃₂N₂O₆
Molecular Weight 576.64
Synonym(s) None
SMILES O=C(O)[C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)CCCNC(OCC4C5=CC=CC=C5C6=CC=CC=C64)=O

Description

Fmoc-Orn(Fmoc)-OH is a doubly protected ornithine derivative featuring two Fmoc groups, enabling efficient incorporation into solid-phase peptide synthesis. The bis-Fmoc protection ensures orthogonal deprotection and minimizes side reactions during chain elongation. This stable, bench-ready reagent simplifies the installation of ornithine residues with high fidelity.

Application

Fmoc-Orn(Fmoc)-OH serves as a bifunctional amino acid building block for solid-phase peptide synthesis, enabling the introduction of ornithine residues with orthogonal protection. The Fmoc group on the α-amino function ensures compatibility with base-labile deprotection, while the second Fmoc moiety on the side-chain amine allows selective activation and coupling under standard conditions. Its stability under routine handling and ease of purification facilitate efficient incorporation into peptide sequences requiring arginine-like functionality or cyclic scaffold construction.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 113.96
LogP 6.2972
H_Acceptors 5
H_Donors 3
Rotatable_Bonds 10

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-Orn(Fmoc)-OH

CAS No. 201046-59-5

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