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CS-W001157 4
Total: USD 88.00

tert-Butyl (3-hydroxyphenyl)carbamate

  • CAS No. 19962-06-2

  • Cat. No. CS-0099712
  • Purity≥96%
  • MDL No.MFCD06798070

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3-hydroxyphenyl)carbamate|CS-0099712

Structure of 19962-06-2

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General Information

  • CAS No. 19962-06-2
  • Cat. No. CS-0099712
  • Purity ≥96%
  • MDL No. MFCD06798070
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO₃
  • Molecular Weight 209.24
  • Synonym(s) tert-butyl N-(3-hydroxyphenyl)carbamate
  • SMILES O=C(OC(C)(C)C)NC1=CC=CC(O)=C1

Description

tert-Butyl (3-hydroxyphenyl)carbamate delivers a protected phenolic hydroxyl group flanked by a robust tert-butyl carbamate moiety, enabling stable incorporation into complex molecular architectures. This derivative facilitates selective functionalization in synthetic sequences where labile hydroxyls must be preserved under reaction conditions.

Application

tert-Butyl (3-hydroxyphenyl)carbamate serves as a stable, bench-ready protecting group for phenolic hydroxyls, enabling selective functionalization in complex molecule synthesis. It functions reliably in standard coupling and reduction protocols, offering excellent compatibility with diverse reaction conditions and facilitating straightforward deprotection under mild acidic conditions.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      51642-25-2
    • ~90%
    • In-stock
      tert-Butyl (3-hydroxyphenyl)carbamate|CS-0099712
      19962-06-2

    References

    • European Journal of Organic Chemistry, , # 22 p. 3740 - 3744
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      591-27-5
    • ~97%
    • In-stock
      tert-Butyl (3-hydroxyphenyl)carbamate|CS-0099712
      19962-06-2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 21, # 22 p. 7107 - 7117
  • Route3
    • null|null
      1239374-10-7
    • ~%
    • In-stock
      tert-Butyl (3-hydroxyphenyl)carbamate|CS-0099712
      19962-06-2

    References

    • European Journal of Organic Chemistry, , # 19 p. 3704 - 3710

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317
Precautionary Statements : P261-P272-P280-P302+P352-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   2.7392
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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