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CS-W001157 4
Total: USD 88.00

Boc-Hyp-OMe

  • CAS No. 74844-91-0

  • Cat. No. CS-W019724
  • Purity≥97%
  • MDL No.MFCD00076981

*For research and further manufacturing use only, not for direct human use.

Boc-Hyp-OMe|CS-W019724

Structure of 74844-91-0

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General Information

  • CAS No. 74844-91-0
  • Cat. No. CS-W019724
  • Purity ≥97%
  • MDL No. MFCD00076981
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₅
  • Molecular Weight 245.27
  • Synonym(s) None
  • SMILES O=C(N1[C@H](C(OC)=O)C[C@@H](O)C1)OC(C)(C)C

Description

Boc-Hyp-OMe delivers a protected hydroxyproline unit with enhanced solubility and stability, enabling efficient incorporation into peptide chains. The Boc group ensures facile deprotection under mild acidic conditions, while the methyl ester facilitates selective derivatization. This derivative simplifies synthetic workflows in peptide synthesis and natural product assembly.

Synthesis

  • Route1

    References

    • Grygorenko, Oleksandr O.; Komarov, Igor V.; Cativiela, Carlos Tetrahedron Asymmetry, 2009 , vol. 20, # 12 p. 1433 - 1436
  • Route2
    • In-stock
      Boc-Hyp-OH|CS-M3078
      13726-69-7
    • null|null
      74-88-4
    • ~96%
    • In-stock
      Boc-Hyp-OMe|CS-W019724
      74844-91-0

    References

    • LG LIFE SCIENCE LTD. Patent: US2010/120783 A1, 2010 ; Location in patent: Page/Page column 10 ; US 20100120783 A1
  • Route3
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • L-Proline, 4-hydroxy-, methyl ester, (4R)-|CS-0015102
      1499-56-5
    • ~97%
    • In-stock
      Boc-Hyp-OMe|CS-W019724
      74844-91-0

    References

    • Tanaka, Fujie; Barbas, Carlos F.; Zhang, Haile Patent: US2007/117986 A1, 2007 ; Location in patent: Page/Page column 21; 22 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   0.5297
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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