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CS-W001157 4
Total: USD 88.00

2-Chloro-4-fluorophenol

  • CAS No. 1996-41-4

  • Cat. No. CS-W007676
  • Purity≥98%
  • MDL No.MFCD00002168

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-fluorophenol|CS-W007676

Structure of 1996-41-4

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General Information

  • CAS No. 1996-41-4
  • Cat. No. CS-W007676
  • Purity ≥98%
  • MDL No. MFCD00002168
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClFO
  • Molecular Weight 146.55
  • Synonym(s) Phenol, 2-chloro-4-fluoro-; 2-Chloro-4-fluorophenol
  • SMILES C1=C(C(=CC=C1F)O)Cl

Description

2-Chloro-4-fluorophenol was used in enzymatic production of fluorocatechols.

Application

2-Chloro-4-fluorophenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl group and ortho/para positions. Its dual halogen substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and nucleophilic aromatic substitution, facilitating the synthesis of complex aryl scaffolds. Bench-stable and amenable to standard purification methods, it functions reliably in multistep syntheses requiring selective transformations.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
  • Route2

    References

    • Bulletin of the Chemical Society of Japan, , vol. 37, p. 583 - 584
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 94,95, 97

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319
Precautionary Statements : P210-P264-P280-P302+P352-P362-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.1847
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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