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CS-W001157 4
Total: USD 88.00

4,6-Difluoro-2,3-dihydro-1h-indole

  • CAS No. 199526-98-2

  • Cat. No. CS-0216270
  • Purity≥95%
  • MDL No.MFCD01075222

*For research and further manufacturing use only, not for direct human use.

4,6-Difluoro-2,3-dihydro-1h-indole|CS-0216270

Structure of 199526-98-2

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General Information

  • CAS No. 199526-98-2
  • Cat. No. CS-0216270
  • Purity ≥95%
  • MDL No. MFCD01075222
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₂N
  • Molecular Weight None
  • Synonym(s) 4,6-Difluoroindoline
  • SMILES C1CNC2=CC(=CC(=C12)F)F

Description

4,6-Difluoro-2,3-dihydro-1H-indole delivers a fluorinated indoline scaffold with enhanced electronic modulation and metabolic stability. The ortho-fluorine substituents at positions 4 and 6 influence reactivity and conformational rigidity, enabling efficient incorporation into bioactive molecules. This bench-stable, moisture-tolerant heterocycle serves as a key intermediate in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Application

4,6-Difluoro-2,3-dihydro-1H-indole serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds with enhanced metabolic stability. Its difluorinated aromatic core facilitates selective functionalization and improves lipophilicity profiles. The compound exhibits good bench stability and compatibility with standard coupling reactions, making it well-suited for modular synthesis of bioactive molecules.

Synthesis

  • Route1

    References

    • PFIZER INC.; Bhattacharya, Samit; Cameron, Kimberly; Dowling, Matthew; Fernando, Dilinie; Ebner, David; Filipski, Kevin; Kung, Daniel; Lee, Esther; Smith, Aaron; Tu, Meihua Patent: US2013/267493 A1, 2013 ; Location in patent: Paragraph 0719 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.9328
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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