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CS-W001157 4
Total: USD 88.00

4,6-Difluoro-2,3-dihydro-1h-indole

  • CAS No. 199526-98-2

  • Cat. No. CS-0216270
  • Purity≥95%
  • MDL No.MFCD01075222
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,6-Difluoro-2,3-dihydro-1h-indole|CS-0216270

Structure of 199526-98-2

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Description

4,6-Difluoro-2,3-dihydro-1H-indole delivers a fluorinated indoline scaffold with enhanced electronic modulation and metabolic stability. The ortho-fluorine substituents at positions 4 and 6 influence reactivity and conformational rigidity, enabling efficient incorporation into bioactive molecules. This bench-stable, moisture-tolerant heterocycle serves as a key intermediate in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Application

4,6-Difluoro-2,3-dihydro-1H-indole serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds with enhanced metabolic stability. Its difluorinated aromatic core facilitates selective functionalization and improves lipophilicity profiles. The compound exhibits good bench stability and compatibility with standard coupling reactions, making it well-suited for modular synthesis of bioactive molecules.

General Information

  • CAS No. 199526-98-2
  • Cat. No. CS-0216270
  • Purity ≥95%
  • MDL No. MFCD01075222
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₂N
  • Molecular Weight None
  • Synonym(s) 4,6-Difluoroindoline
  • SMILES C1CNC2=CC(=CC(=C12)F)F

Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.9328
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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