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CS-W001157 4
Total: USD 88.00

5-(Trifluoromethyl)indoline

  • CAS No. 162100-55-2

  • Cat. No. CS-W018757
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethyl)indoline|CS-W018757

Structure of 162100-55-2

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General Information

  • CAS No. 162100-55-2
  • Cat. No. CS-W018757
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈F₃N
  • Molecular Weight 187.16
  • Synonym(s) 5-Trifluoromethylindoline 5-(Trifluoromethyl)-2,3-dihydro-1H-indole in stock Factory
  • SMILES FC(C1=CC2=C(NCC2)C=C1)(F)F

Description

5-(Trifluoromethyl)indoline features a trifluoromethyl group at the 5-position of the indoline scaffold, imparting enhanced electron-withdrawing character and metabolic stability. This bench-stable heterocycle integrates readily into pharmaceutical scaffolds, serving as a key building block for bioactive molecules in medicinal chemistry.

Application

5-(Trifluoromethyl)indoline serves as a valuable building block in medicinal chemistry, offering enhanced metabolic stability and lipophilicity due to the electron-withdrawing trifluoromethyl group. Its indoline core facilitates integration into diverse heterocyclic scaffolds, while the pendant amine enables straightforward derivatization. The compound exhibits good bench stability and is compatible with standard coupling and functionalization protocols, making it a practical choice for synthesizing kinase inhibitors, CNS-targeted agents, and other bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.6734
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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