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CS-W001157 4
Total: USD 88.00

3,6-Difluoropicolinic acid

  • CAS No. 851386-45-3

  • Cat. No. CS-0094698
  • Purity≥97%
  • MDL No.MFCD09031176

*For research and further manufacturing use only, not for direct human use.

3,6-Difluoropicolinic acid|CS-0094698

Structure of 851386-45-3

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General Information

  • CAS No. 851386-45-3
  • Cat. No. CS-0094698
  • Purity ≥97%
  • MDL No. MFCD09031176
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) 3,6-difluoropyridine-2-carboxylic Acid
  • SMILES O=C(C1=NC(F)=CC=C1F)O

Description

3,6-Difluoropicolinic acid is a fluorinated pyridine carboxylic acid featuring electron-withdrawing fluorine substituents at the 3- and 6-positions. This configuration enhances its electrophilicity and metabolic stability, making it a valuable building block for pharmaceutical intermediates and bioactive heterocycles. The molecule exhibits favorable solubility in polar organic solvents and maintains bench stability under standard conditions.

Application

3,6-Difluoropicolinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive molecules. Its dual fluorine substituents enhance metabolic stability and modulate electronic properties, while the carboxylic acid group facilitates straightforward derivatization via amide coupling or esterification. The compound exhibits good bench stability and compatibility with standard synthetic protocols, making it a practical choice for API intermediate development and structure-activity studies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.058
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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