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CS-W001157 4
Total: USD 88.00

5,6-Difluoropicolinic acid

  • CAS No. 851386-38-4

  • Cat. No. CS-0088897
  • Purity≥97%
  • MDL No.MFCD09031175

*For research and further manufacturing use only, not for direct human use.

5,6-Difluoropicolinic acid|CS-0088897

Structure of 851386-38-4

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General Information

  • CAS No. 851386-38-4
  • Cat. No. CS-0088897
  • Purity ≥97%
  • MDL No. MFCD09031175
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) 5,6-difluoropyridine-2-carboxylic Acid
  • SMILES O=C(C1=NC(F)=C(F)C=C1)O

Description

5,6-Difluoropicolinic acid is a fluorinated pyridine carboxylic acid featuring two strategically positioned fluorine atoms that enhance metabolic stability and influence electronic properties. This electron-deficient heterocycle integrates readily into bioactive scaffolds, serving as a key building block in medicinal chemistry for modulating solubility, membrane permeability, and target binding affinity.

Application

5,6-Difluoropicolinic acid serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated heterocyclic scaffolds through standard coupling and cyclization protocols. Its ortho-difluoro substitution enhances metabolic stability and modulates electronic properties, facilitating targeted interactions in biological systems. The carboxylic acid functionality allows straightforward derivatization via amide, ester, or amidation reactions, supporting diverse synthetic workflows. Bench-stable and compatible with common reaction conditions, it functions reliably in peptide-like conjugations and API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.058
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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