Fmoc-Phe(4-Me)-OH

Name: Fmoc-Phe(4-Me)-OH
Brand: ChemScene
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CAS No. 199006-54-7
Cat. No. CS-W016747
Purity≥97%
MDL No.MFCD00270197

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 199006-54-7

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General Information

CAS No. 199006-54-7
Cat. No. CS-W016747
Purity ≥97%
MDL No. MFCD00270197
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₃NO₄
Molecular Weight 401.45
Synonym(s) None
SMILES O=C([C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CC4=CC=C(C=C4)C)O

Description

Fmoc-Phe(4-Me)-OH is a sterically hindered, bench-stable amino acid derivative featuring a para-methyl group that enhances hydrophobicity and metabolic stability. This modification improves incorporation efficiency in peptide synthesis and supports the construction of biologically active sequences with enhanced membrane permeability.

Application

Fmoc-Phe(4-Me)-OH serves as a valuable building block in peptide synthesis, offering enhanced hydrophobicity and steric bulk via the 4-methyl substitution on the phenyl ring. The Fmoc group enables efficient base-labile protection for N-terminal amine control, while the side chain remains inert under standard coupling conditions. This derivative facilitates incorporation of tyrosine-like motifs with improved metabolic stability and is well-suited for solid-phase peptide synthesis workflows requiring robust handling and high-purity product isolation.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 4.52942
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Life Science Amino Acids and their Derivatives N-protected amino acid

Building Blocks Functional Group Fmoc

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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Fmoc-Phe(4-Me)-OH

CAS No. 199006-54-7

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