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CS-W001157 4
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(S)-6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octane-7-carboxylic acid

  • CAS No. 1980007-51-9

  • Cat. No. CS-0255707
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octane-7-carboxylic acid|CS-0255707

Structure of 1980007-51-9

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General Information

  • CAS No. 1980007-51-9
  • Cat. No. CS-0255707
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₁NO₄
  • Molecular Weight 255.31
  • Synonym(s) N-Boc-4-cyclobutyl-L-proline
  • SMILES O=C(N([C@H](C(O)=O)C1)CC21CCC2)OC(C)(C)C

Description

This chiral spirocyclic scaffold features a protected amine and carboxylic acid, enabling direct incorporation into peptide-like architectures. The tert-butoxycarbonyl group ensures stability during synthesis, while the azaspiro framework imparts conformational rigidity ideal for medicinal chemistry applications.

Application

(S)-6-(tert-Butoxycarbonyl)-6-azaspiro[3.4]octane-7-carboxylic acid serves as a stereocontrolled building block for spirocyclic scaffolds prevalent in medicinal chemistry. The protected amine and carboxylic acid functionalities enable sequential derivatization, including deprotection, coupling, and cyclization reactions. Its robust tert-butoxycarbonyl group offers excellent bench stability and compatibility with standard peptide synthesis protocols, facilitating efficient access to complex nitrogen-containing heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.2507
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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