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CS-W001157 4
Total: USD 88.00

1-(3,4-Dimethoxyphenyl)propan-2-ol

  • CAS No. 19578-92-8

  • Cat. No. CS-0092697
  • Purity≥95%
  • MDL No.MFCD01697000

*For research and further manufacturing use only, not for direct human use.

1-(3,4-Dimethoxyphenyl)propan-2-ol|CS-0092697

Structure of 19578-92-8

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General Information

  • CAS No. 19578-92-8
  • Cat. No. CS-0092697
  • Purity ≥95%
  • MDL No. MFCD01697000
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆O₃
  • Molecular Weight 196.24
  • Synonym(s) 1-(3,4-Dimethoxyphenyl)-2-propanol
  • SMILES COC1=C(OC)C=CC(CC(O)C)=C1

Description

This bench-stable, moisture-tolerant phenolic alcohol integrates a 3,4-dimethoxyphenyl moiety with a propan-2-ol backbone, enabling direct incorporation into bioactive scaffolds. The electron-rich aromatic system enhances reactivity in coupling processes, while the secondary alcohol offers versatile functionalization points for synthetic elaboration.

Application

1-(3,4-Dimethoxyphenyl)propan-2-ol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through established coupling and functionalization protocols. Its benzylic alcohol functionality offers reliable reactivity for oxidation, protection, or derivatization, while the ortho-dimethoxy substitution pattern enhances metabolic stability and modulates lipophilicity. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      776-99-8
    • ~97%
    • In-stock
      1-(3,4-Dimethoxyphenyl)propan-2-ol|CS-0092697
      19578-92-8

    References

    • Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V. Organic Letters, 2013 , vol. 15, # 9 p. 2278 - 2281
  • Route2

    References

    • Manitto,P. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 1548 - 1551
  • Route3
    • null|null
      37629-53-1
    • ~%
    • In-stock
      1-(3,4-Dimethoxyphenyl)propan-2-ol|CS-0092697
      19578-92-8

    References

    • Morgan,P.H.; Beckett,A.H. Tetrahedron, 1975 , vol. 31, p. 2595 - 2601

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   1.6271
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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