Fmoc-D-β-Pro-OH

Name: Fmoc-D-β-Pro-OH
Brand: ChemScene
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CAS No. 193693-65-1
Cat. No. CS-0173481
Purity≥98%
MDL No.MFCD14635841

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 193693-65-1

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General Information

CAS No. 193693-65-1
Cat. No. CS-0173481
Purity ≥98%
MDL No. MFCD14635841
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₁₉NO₄
Molecular Weight 337.38
Synonym(s) (R)-1-Fmoc-3-pyrrolidinecarboxylic acid
SMILES O=C(N1C[C@H](C(O)=O)CC1)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3

Description

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-3-carboxylic acid features a chiral pyrrolidine core with a fluorenylmethoxycarbonyl (Fmoc) protecting group, enabling reliable incorporation into peptide synthesis. This configuration ensures stereochemical integrity during coupling steps and facilitates purification via standard chromatographic methods. The Fmoc moiety offers orthogonal deprotection under mild basic conditions, streamlining sequential assembly in solid-phase workflows.

Application

(R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-3-carboxylic acid serves as a robust chiral building block for peptide synthesis and medicinal chemistry campaigns. Its fluorenylmethoxycarbonyl (Fmoc) protection offers high stability under basic conditions and facile removal via mild base treatment. The pyrrolidine-3-carboxylic acid core provides conformational rigidity and enhanced solubility, enabling efficient incorporation into diverse peptidomimetics and bioactive scaffolds.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

TPSA 66.84
LogP 3.342
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Fmoc-D-β-Pro-OH

CAS No. 193693-65-1

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