N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-ethyl-N-methyl-L-serine

Name: N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-ethyl-N-methyl-L-serine
Brand: ChemScene
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CAS No. 1931107-98-0
Cat. No. CS-0096678
Purity≥97%
MDL No.None

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N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-ethyl-N-methyl-L-serine|CS-0096678

Structure of 1931107-98-0

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Description

This fluorenylmethoxycarbonyl-protected serine derivative features a stable, electron-rich fluoren-9-ylmethoxy carbonyl group that enables efficient coupling in peptide synthesis. The O-ethyl and N-methyl substitutions enhance solubility and reduce side reactions, while the protected hydroxyl and amino groups provide orthogonal functionality for sequential derivatization.

Application

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-ethyl-N-methyl-L-serine serves as a versatile, bench-stable amino acid derivative for solid-phase peptide synthesis. Its Fmoc group enables orthogonal protection, while the O-ethyl and N-methyl functionalities provide enhanced solubility and reduced racemization risk during coupling. The molecule facilitates efficient incorporation of modified serine residues into peptide sequences, supporting both manual and automated synthesis workflows with high fidelity and ease of purification.

General Information

CAS No. 1931107-98-0
Cat. No. CS-0096678
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₃NO₅
Molecular Weight 369.41
Synonym(s) None
SMILES O=C(O)[C@H](COCC)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C

Computational Chemistry Data

TPSA 76.07
LogP 3.357
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 7

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Drug Discovery Cancer KRAS

Key Words

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N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-O-ethyl-N-methyl-L-serine

CAS No. 1931107-98-0

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