N-Fmoc-N,O-dimethyl-L-serine

Name: N-Fmoc-N,O-dimethyl-L-serine
Brand: ChemScene
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CAS No. 1569103-64-5
Cat. No. CS-0096677
Purity≥96%
MDL No.MFCD31730320

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1569103-64-5
Cat. No. CS-0096677
Purity ≥96%
MDL No. MFCD31730320
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₂₁NO₅
Molecular Weight 355.38
Synonym(s) None
SMILES COC[C@@H](C(O)=O)N(C)C(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Description

N-Fmoc-N,O-dimethyl-L-serine integrates a protected serine scaffold with orthogonal functional handles, enabling direct incorporation into peptide chains. The Fmoc group facilitates efficient solid-phase synthesis, while the dimethylated hydroxyl and nitrogen provide enhanced stability and resistance to side reactions under standard coupling conditions.

Application

N-Fmoc-N,O-dimethyl-L-serine serves as a versatile building block for peptide synthesis, enabling efficient incorporation of side-chain-modified serine residues. The Fmoc group provides orthogonal protection for the amine, while the O-methyl and N-methyl functionalities enhance stability and reduce undesired side reactions. This derivative facilitates rapid purification and is compatible with standard coupling protocols in solid-phase peptide synthesis.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 76.07
LogP 2.9669
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 6

Other Classifications

Life Science Amino Acids and their Derivatives Serine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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N-Fmoc-N,O-dimethyl-L-serine

CAS No. 1569103-64-5

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