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CS-W001157 4
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(S)-2-Chloropropan-1-ol

  • CAS No. 19210-21-0

  • Cat. No. CS-W016664
  • Purity≥98%
  • MDL No.MFCD00010812

*For research and further manufacturing use only, not for direct human use.

(S)-2-Chloropropan-1-ol|CS-W016664

Structure of 19210-21-0

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General Information

  • CAS No. 19210-21-0
  • Cat. No. CS-W016664
  • Purity ≥98%
  • MDL No. MFCD00010812
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇ClO
  • Molecular Weight 94.54
  • Synonym(s) 2,3-Dichloroprop-1-Ene
  • SMILES C[C@H](Cl)CO

Description

(S)-2-Chloropropan-1-ol is a chiral synthon featuring a stereodefined hydroxyl group and a chlorine atom at the adjacent carbon. This configuration enables selective transformations in asymmetric synthesis, particularly in nucleophilic substitution and coupling reactions. The molecule exhibits enhanced reactivity compared to its racemic counterpart due to defined stereochemistry, making it valuable for constructing enantiopure intermediates in pharmaceutical and agrochemical development.

Application

(S)-2-Chloropropan-1-ol serves as a chiral building block for stereoselective synthesis, enabling efficient access to functionalized intermediates via nucleophilic substitution. Its bench-stable nature and well-defined stereochemistry facilitate reliable incorporation into pharmaceutical and agrochemical scaffolds. Functions effectively in coupling reactions and as a precursor for heterocyclic ring formation under standard conditions.

Synthesis

  • Route1
    • null|null
      16088-62-3
    • ~%
    • In-stock
      (S)-2-Chloropropan-1-ol|CS-W016664
      19210-21-0
    • In-stock
      (S)-1-Chloropropan-2-ol|CS-0158252
      37493-16-6

    References

    • US2011/130377 A1, ; Page/Page column 19 ;
  • Route2

    References

    • Koppenhoefer, Bernhard; Weber, Roland; Schurig, Volker Synthesis, 1982 , # 4 p. 316 - 318
  • Route3
    • null|null
      104897-94-1
    • ~39%
    • In-stock
      (S)-2-Chloropropan-1-ol|CS-W016664
      19210-21-0
    • null|null
      96303-88-7

    References

    • Tetrahedron Letters, , vol. 26, # 41 p. 5037 - 5040

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 2611
Class : 6.1 (3)
Packing Group : Ⅱ
Hazard Statements : H226-H302+H312+H332-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.606
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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