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CS-W001157 4
Total: USD 88.00

2-Hydroxy-6-(trifluoromethyl)nicotinic acid

  • CAS No. 191595-63-8

  • Cat. No. CS-W009086
  • Molecule weight207.11
  • Purity≥97%
  • MDL No.MFCD01862657

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-6-(trifluoromethyl)nicotinic acid|CS-W009086

Structure of 191595-63-8

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General Information

  • CAS No. 191595-63-8
  • Cat. No. CS-W009086
  • Purity ≥97%
  • MDL No. MFCD01862657
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₃NO₃
  • Molecular Weight 207.11
  • Synonym(s) 2-hydroxy-6-(trifluoromethyl)pyridine-3-carboxylic acid
  • SMILES O=C(O)C1=C(O)N=C(C(F)(F)F)C=C1

Description

This trifluoromethyl-substituted nicotinic acid derivative features a strategically positioned hydroxyl group that enhances solubility and reactivity. The electron-withdrawing trifluoromethyl moiety modulates acidity and stability, enabling its use in synthetic routes to bioactive heterocycles and pharmaceutical intermediates under standard conditions.

Application

2-Hydroxy-6-(trifluoromethyl)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the ortho-hydroxyl and carboxylic acid functionalities provide sites for derivatization via esterification, amidation, or cyclization reactions. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for scalable synthesis workflows in API development.

Synthesis

  • Route1
    • 2-Oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide|CS-0082220
      116548-03-9
    • ~%
    • In-stock
      2-Hydroxy-6-(trifluoromethyl)nicotinic acid|CS-W009086
      191595-63-8

    References

    • WO2007/41052 A2, ; Page/Page column 82 ; WO 2007/041052 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   1.5042
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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