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CS-W001157 4
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2-Hydroxy-6-methylnicotinic acid

  • CAS No. 38116-61-9

  • Cat. No. CS-W014340
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-6-methylnicotinic acid|CS-W014340

Structure of 38116-61-9

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General Information

  • CAS No. 38116-61-9
  • Cat. No. CS-W014340
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate
  • SMILES O=C(O)C1=C(O)N=C(C)C=C1

Description

2-Hydroxy-6-methylnicotinic acid features a strategically positioned hydroxyl group and methyl substituent on the pyridine ring, enhancing its solubility and reactivity in synthetic transformations. This configuration supports efficient coupling reactions and serves as a key scaffold in bioactive molecule design.

Application

2-Hydroxy-6-methylnicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted nicotinamide derivatives and heterocyclic scaffolds. Its ortho-hydroxyl and methyl groups provide defined regiochemistry for downstream functionalization, including esterification, amidation, and metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • Dornow Chemische Berichte, 1940 , vol. 73, p. 156 Full Text Show Details Matsukawa; Matsuno Yakugaku Zasshi, 1944 , vol. 64, # 3 p. 145,150 Chem.Abstr., 1951 , p. 4724 Full Text Show Details Kotschetkow Doklady Akademii Nauk SSSR, 1952 , vol. 84, p. 289,292 Chem.Abstr., 1953 , p. 3309 Full Text Show Details Franke et al. Chemische Berichte, 1953 , vol. 86, p. 793,795

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.79382
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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