N-Methylpiperidine-4-carboxamide hydrochloride

Name: N-Methylpiperidine-4-carboxamide hydrochloride
Brand: ChemScene
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CAS No. 1903-75-9
Cat. No. CS-0141261
Purity≥97%
MDL No.MFCD11615742

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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N-Methylpiperidine-4-carboxamide hydrochloride|CS-0141261

Structure of 1903-75-9

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General Information

CAS No. 1903-75-9
Cat. No. CS-0141261
Purity ≥97%
MDL No. MFCD11615742
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₅ClN₂O
Molecular Weight 178.66
Synonym(s) N-METHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE
SMILES O=C(C1CCNCC1)NC.[H]Cl

Description

N-Methylpiperidine-4-carboxamide hydrochloride features a rigid, electron-rich piperidine core paired with a polar amide functionality, enabling strong hydrogen bonding and enhanced solubility in aqueous and protic solvents. This combination supports efficient incorporation into bioactive molecules, particularly in kinase inhibitors and CNS-targeted therapeutics, where metabolic stability and membrane permeability are critical. The hydrochloride salt form ensures improved crystallinity and handling under standard bench conditions.

Application

N-Methylpiperidine-4-carboxamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through standard amide coupling and reductive amination protocols. Its stability under routine synthetic conditions, combined with favorable solubility and ease of purification, facilitates integration into high-throughput synthesis workflows. Functions effectively as a key intermediate in the construction of heterocyclic pharmacophores and peptide-like motifs.

Synthesis

Route1
- 6843-37-4
- ~99%
- In-stock
  
  1903-75-9
References
- Cheng, Chuanjie; Xu, Jimin; Zhu, Rui; Xing, Lixin; Wang, Xinyan; Hu, Yuefei Tetrahedron, 2009 , vol. 65, # 41 p. 8538 - 8541

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 41.13
LogP 0.1538
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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N-Methylpiperidine-4-carboxamide hydrochloride

CAS No. 1903-75-9

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