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CS-W001157 4
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Thiazol-2-yl-acetic acid

  • CAS No. 188937-16-8

  • Cat. No. CS-W002885
  • Purity≥95%
  • MDL No.MFCD02094168

*For research and further manufacturing use only, not for direct human use.

Thiazol-2-yl-acetic acid|CS-W002885

Structure of 188937-16-8

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General Information

  • CAS No. 188937-16-8
  • Cat. No. CS-W002885
  • Purity ≥95%
  • MDL No. MFCD02094168
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₂S
  • Molecular Weight None
  • Synonym(s) 2-Thiazoleacetic acid
  • SMILES O=C(O)CC1=NC=CS1

Description

Thiazol-2-yl-acetic acid features a thiazole ring linked to a carboxylic acid group, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in kinase inhibitors and antimicrobial agents. The acidic proton enables salt formation, improving formulation compatibility.

Application

Thiazol-2-yl-acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiazole-containing bioactive molecules. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions, while the thiazole ring provides metabolic stability and enhanced target affinity. The molecule exhibits good bench stability and compatibility with standard purification methods, making it suitable for scalable synthesis of API intermediates and heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.7702
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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