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CS-W001157 4
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2-(Thiazol-2-yl)acetonitrile

  • CAS No. 101010-74-6

  • Cat. No. CS-0051787
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Thiazol-2-yl)acetonitrile|CS-0051787

Structure of 101010-74-6

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General Information

  • CAS No. 101010-74-6
  • Cat. No. CS-0051787
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂S
  • Molecular Weight 124.16
  • Synonym(s) Thiazol-2-YL-acetonitrile
  • SMILES N#CCC1=NC=CS1

Description

2-(Thiazol-2-yl)acetonitrile features a thiazole ring linked to an acetonitrile group, delivering a versatile scaffold for synthetic transformations. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates and functional materials, offering enhanced reactivity in nucleophilic substitution and transition metal-catalyzed coupling reactions under standard conditions.

Application

2-(Thiazol-2-yl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of thiazole-containing scaffolds via nucleophilic addition or transition-metal-catalyzed coupling. The nitrile group facilitates downstream functionalization through hydrolysis or reduction, while the thiazole ring provides structural rigidity and favorable pharmacophoric properties. Bench-stable and compatible with standard purification methods, it functions reliably in multistep synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   36.68
  • LogP   1.20918
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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