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CS-W001157 4
Total: USD 88.00

(6-Methyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid

  • CAS No. 1889221-15-1

  • Cat. No. CS-0162260
  • Purity≥98%
  • MDL No.MFCD20923615

*For research and further manufacturing use only, not for direct human use.

(6-Methyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid|CS-0162260

Structure of 1889221-15-1

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General Information

  • CAS No. 1889221-15-1
  • Cat. No. CS-0162260
  • Purity ≥98%
  • MDL No. MFCD20923615
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BF₃NO₂
  • Molecular Weight 204.94
  • Synonym(s) 6-Methyl-5-trifluoromethylpyridine-3-boronic acid
  • SMILES FC(C1=C(C)N=CC(B(O)O)=C1)(F)F

Description

This boronate moiety features a 6-methyl-5-(trifluoromethyl)pyridin-3-yl scaffold, combining electron-deficient heteroaromaticity with enhanced stability. The trifluoromethyl group imparts strong lipophilicity and metabolic resistance, while the boronic acid enables efficient Suzuki-Miyaura cross-coupling under standard conditions. This bench-stable reagent streamlines access to complex pyridine-based architectures in medicinal chemistry and materials science.

Application

(6-Methyl-5-(trifluoromethyl)pyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its trifluoromethyl and methyl substituents enhance metabolic stability and modulate electronic properties, while the boronic acid group offers excellent bench stability and compatibility with diverse reaction conditions. Ideal for medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds, it facilitates rapid diversification through reliable, high-yielding couplings.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   0.08862
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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