Lot numbers can be found on the outside label of a product:
1-(tert-Butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid
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CAS No. 188792-67-8
- Cat. No. CS-W003463
- Purity≥98%
- MDL No.MFCD08062529
*For research and further manufacturing use only, not for direct human use.
Structure of 188792-67-8
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General Information
- CAS No. 188792-67-8
- Cat. No. CS-W003463
- Purity ≥98%
- MDL No. MFCD08062529
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₃H₂₃NO₄
- Molecular Weight 257.33
- Synonym(s) 1-Boc-4-Ethyl-4-Piperidinecarboxylic Acid
- SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)C(=O)O
Description
This piperidine derivative features a tert-butoxycarbonyl-protected amine and an ethyl-substituted carboxylic acid, enabling direct incorporation into peptide synthesis. The protected nitrogen facilitates sequential coupling without side reactions, while the electron-rich piperidine ring enhances solubility under standard conditions.
Application
1-(tert-Butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds through straightforward deprotection and functionalization. The tert-butyl carbamate group offers excellent stability under basic conditions and facilitates selective N-alkylation or amide coupling reactions. Its ethyl-substituted piperidine core provides defined stereochemistry and enhanced lipophilicity, making it valuable for optimizing pharmacokinetic properties in API development.
Synthesis
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Route1
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In-stock
578021-55-3 - ~%
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In-stock
188792-67-8
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 14 p. 3675 - 3678
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Route2
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In-stock
124443-68-1 - ~%
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In-stock
188792-67-8
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 14 p. 3675 - 3678
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Route3
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In-stock
1126-09-6 - ~%
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In-stock
188792-67-8
References
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US2011/15196 A1, ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 66.84
- LogP 2.4983
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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