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CS-W001157 4
Total: USD 88.00

3,4-Dichloropyridin-2-amine

  • CAS No. 188577-69-7

  • Cat. No. CS-0051608
  • Molecule weight163.00
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,4-Dichloropyridin-2-amine|CS-0051608

Structure of 188577-69-7

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General Information

  • CAS No. 188577-69-7
  • Cat. No. CS-0051608
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄Cl₂N₂
  • Molecular Weight 163.00
  • Synonym(s) 3,4-Dichloro-2-pyridinamine
  • SMILES NC1=NC=CC(Cl)=C1Cl

Description

3,4-Dichloropyridin-2-amine features a pyridine core substituted with chlorine atoms at the 3 and 4 positions and an amino group at the 2 position. This electron-deficient heterocycle serves as a key scaffold in medicinal chemistry, enabling efficient coupling reactions. The molecule exhibits enhanced stability under standard conditions and facilitates rapid functionalization in synthetic pathways.

Application

3,4-Dichloropyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its dual chlorine substituents provide orthogonal reactivity for sequential functionalization, while the pyridin-2-amine moiety offers a readily derivatizable nitrogen for amide formation or metal coordination. Bench-stable and compatible with standard reaction conditions, it facilitates streamlined synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.9706
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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