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(R)-1-(3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-yl)-2,5-diphenyl-1H-pyrrole

  • CAS No. 1884457-40-2

  • Cat. No. CS-0088801
  • Purity≥97%
  • MDL No.MFCD31707609

*For research and further manufacturing use only, not for direct human use.

(R)-1-(3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-yl)-2,5-diphenyl-1H-pyrrole|CS-0088801

Structure of 1884457-40-2

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General Information

  • CAS No. 1884457-40-2
  • Cat. No. CS-0088801
  • Purity ≥97%
  • MDL No. MFCD31707609
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₂₆NOP
  • Molecular Weight 411.48
  • Synonym(s) 5-diphenyl-1H-pyrrole
  • SMILES CC(C)(C)[P@@]1C2=C(N3C(C4=CC=CC=C4)=CC=C3C5=CC=CC=C5)C=CC=C2OC1

Description

(R)-1-(3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-yl)-2,5-diphenyl-1H-pyrrole features a chiral phosphole core with steric protection from the tert-butyl group, enhancing stability and selectivity. The diphenyl-substituted pyrrole moiety provides electron-rich character, facilitating coupling reactions in asymmetric synthesis. This structure enables efficient integration into catalytic systems requiring defined stereochemistry and robust functional group tolerance under standard conditions.

Application

(R)-1-(3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-yl)-2,5-diphenyl-1H-pyrrole serves as a sterically encumbered phosphorus-containing heterocycle that facilitates stereoselective transformations in asymmetric synthesis. Its bench-stable structure enables reliable use in catalytic systems and coupling reactions, with the oxaphosphole core providing orthogonal reactivity for functional group manipulation. The diphenylpyrrole scaffold offers structural rigidity and electronic tunability, making it suitable for advanced synthetic intermediates in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   14.16
  • LogP   7.0669
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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