Lot numbers can be found on the outside label of a product:
Fmoc-Hyp(Bom)-OH
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CAS No. 187223-15-0
- Cat. No. CS-M3347
- Purity≥98%
- MDL No.MFCD07366898
*For research and further manufacturing use only, not for direct human use.
Structure of 187223-15-0
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General Information
- CAS No. 187223-15-0
- Cat. No. CS-M3347
- Purity ≥98%
- MDL No. MFCD07366898
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₈H₃₃N₃O₈
- Molecular Weight 539.58
- Synonym(s) None
- SMILES O=C(O)[C@@H]1C[C@@H](OC(NCCNC(OC(C)(C)C)=O)=O)CN1C(OCC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O
Description
Fmoc-Hyp(Bom)-OH is a protected hydroxyproline derivative featuring a benzyloxycarbonyl group on the hydroxyl moiety, enhancing stability and enabling orthogonal deprotection. This analog integrates seamlessly into peptide synthesis workflows, offering precise control over post-translational modifications in bioactive peptide design.
Application
Fmoc-Hyp(Bom)-OH serves as a key building block in peptide synthesis, enabling the incorporation of hydroxyproline with orthogonal protection. The Fmoc group allows for efficient base-labile deprotection, while the Bom (benzyloxycarbonyl) moiety provides stable protection of the hydroxyl function, facilitating selective transformations. This derivative exhibits excellent bench stability and compatibility with standard coupling protocols, supporting reliable access to proline-rich sequences and complex peptide scaffolds.
Synthesis
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Route1
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In-stock
82911-69-1 -
556796-29-3 - ~%
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In-stock
187223-15-0
References
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NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2004/52817 A1, 2004 ; Location in patent: Page 19-20 ;
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Route2
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In-stock
82911-69-1
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187223-14-9
- ~70%
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In-stock
187223-15-0
References
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Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
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Route3
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In-stock
82911-69-1
- ~%
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In-stock
187223-15-0
References
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Lewis, Ian; Bauer, Wilfried; Albert, Rainer; Chandramouli, Nagarajan; Pless, Janos; Weckbecker, Gisbert; Bruns, Christian Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2334 - 2344
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 143.5
- LogP 3.7139
- H_Acceptors 7
- H_Donors 3
- Rotatable_Bonds 7
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Key Words
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