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CS-W001157 4
Total: USD 88.00

2,4-Dimethoxypyridine

  • CAS No. 18677-43-5

  • Cat. No. CS-W018921
  • Purity≥98%
  • MDL No.MFCD01646187

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethoxypyridine|CS-W018921

Structure of 18677-43-5

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General Information

  • CAS No. 18677-43-5
  • Cat. No. CS-W018921
  • Purity ≥98%
  • MDL No. MFCD01646187
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₂
  • Molecular Weight 139.15
  • Synonym(s) 2-heptenal, (2E)-
  • SMILES COC1=CC(OC)=NC=C1

Description

2,4-Dimethoxypyridine features two methoxy groups at the 2- and 4-positions of the pyridine ring, enhancing electron density and directing electrophilic substitution. This bench-stable, moisture-tolerant heterocycle integrates readily into cross-coupling reactions and serves as a key scaffold in medicinal chemistry and agrochemical synthesis.

Application

2,4-Dimethoxypyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds. Its ortho-dialkoxy substitution pattern enhances electrophilic aromatic substitution reactivity while providing stable, bench-ready functionality for subsequent transformations. The molecule functions effectively in cross-coupling reactions and serves as a key intermediate in the synthesis of bioactive compounds and pharmaceutical candidates.

Synthesis

  • Route1
    • In-stock
      2,4-Dichloropyridine|CS-W004774
      26452-80-2
    • null|null
      124-41-4
    • ~53%
    • In-stock
      2,4-Dimethoxypyridine|CS-W018921
      18677-43-5

    References

    • Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D. Patent: US2014/94456 A1, 2014 ; Location in patent: Paragraph 0883-0884 ;
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 50, # 14 p. 2462 - 2468
  • Route3
    • In-stock
      2-Chloro-4-methoxypyridine|CS-W007914
      17228-69-2
    • null|null
      124-41-4
    • ~58%
    • In-stock
      2,4-Dimethoxypyridine|CS-W018921
      18677-43-5

    References

    • JANSSEN PHARMACEUTICA N.V.; ADDEX PHARMACEUTICALS S.A. Patent: WO2006/30032 A1, 2006 ; Location in patent: Page/Page column 114 ; WO 2006/030032 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.0988
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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