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Methyl 3-amino-2-hydroxypropionate hydrochloride

  • CAS No. 186393-00-0

  • Cat. No. CS-0042395
  • Purity≥98%
  • MDL No.MFCD22741315

*For research and further manufacturing use only, not for direct human use.

Methyl 3-amino-2-hydroxypropionate hydrochloride|CS-0042395

Structure of 186393-00-0

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General Information

  • CAS No. 186393-00-0
  • Cat. No. CS-0042395
  • Purity ≥98%
  • MDL No. MFCD22741315
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀ClNO₃
  • Molecular Weight 155.58
  • Synonym(s) Methyl 3-amino-2-hydroxypropanoate hydrochloride
  • SMILES O=C(OC)C(O)CN.Cl

Description

Methyl 3-amino-2-hydroxypropionate hydrochloride is a bench-stable, moisture-tolerant amino acid derivative featuring a primary amine and a vicinal hydroxyl group. This bifunctional scaffold enables direct incorporation into peptide backbones or conjugation workflows, offering enhanced solubility and reactivity in aqueous and polar organic media.

Application

Methyl 3-amino-2-hydroxypropionate hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to β-amino alcohol motifs via standard reductive amination and cyclization protocols. Its amine and hydroxyl functionalities offer orthogonal reactivity for selective derivatization, while the hydrochloride salt ensures excellent bench stability and ease of handling. Functions as a key intermediate in the synthesis of chiral heterocycles and bioactive scaffolds requiring precise stereocontrol.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   -1.0992
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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