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CS-W001157 4
Total: USD 88.00

(5-Fluoro-6-methyl-3-pyridyl)boronicacid

  • CAS No. 1858215-94-7

  • Cat. No. CS-0310145
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(5-Fluoro-6-methyl-3-pyridyl)boronicacid|CS-0310145

Structure of 1858215-94-7

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General Information

  • CAS No. 1858215-94-7
  • Cat. No. CS-0310145
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BFNO₂
  • Molecular Weight 154.93
  • Synonym(s) None
  • SMILES OB(O)C1=CC(F)=C(C)N=C1

Description

This boronate moiety integrates a 5-fluoro-6-methyl-3-pyridyl scaffold, delivering enhanced stability and solubility in polar solvents. The electron-deficient pyridine ring enables efficient coupling in Suzuki-Miyaura reactions, while the methyl and fluorine substituents modulate reactivity and metabolic resistance.

Application

(5-Fluoro-6-methyl-3-pyridyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The fluorine and methyl substituents provide orthogonal electronic tuning and enhanced metabolic stability in medicinal chemistry applications. Bench-stable and readily purified by recrystallization, it exhibits broad functional group tolerance and reliable coupling efficiency under standard reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.79108
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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