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CS-W001157 4
Total: USD 88.00

(S)-MorfPhos

  • CAS No. 185449-81-4

  • Cat. No. CS-0085218
  • Purity≥95%
  • MDL No.MFCD08276866

*For research and further manufacturing use only, not for direct human use.

(S)-MorfPhos|CS-0085218

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General Information

  • CAS No. 185449-81-4
  • Cat. No. CS-0085218
  • Purity ≥95%
  • MDL No. MFCD08276866
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₀NO₃P
  • Molecular Weight 401.39
  • Synonym(s) 3,4-a']dinaphthalen-4-yl)Morpholine (S)-MorfPhos
  • SMILES C12=CC=CC=C1C=CC3=[C@]2[C@]4=C(C=CC=C5)C5=CC=C4OP(N6CCOCC6)O3

Description

(S)-MorfPhos is a chiral phosphine ligand designed for asymmetric catalysis, featuring a rigid, electron-rich architecture that enhances enantioselectivity in transition metal-catalyzed reactions. This bench-stable, moisture-tolerant ligand integrates seamlessly into palladium- and nickel-mediated cross-coupling processes, delivering high stereocontrol under standard conditions.

Application

(S)-MorfPhos serves as a highly effective chiral ligand in palladium-catalyzed cross-coupling reactions, enabling efficient asymmetric synthesis of biaryl and alkenyl compounds. Its robust stereochemical integrity and broad functional group tolerance facilitate reliable enantioselective transformations under standard reaction conditions. The ligand exhibits excellent bench stability and simplifies purification in scalable processes, making it a practical choice for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.75
  • LogP   6.5646
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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