Benzothiophene-3-sulfonyl chloride

Name: Benzothiophene-3-sulfonyl chloride
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 18494-87-6
Cat. No. CS-W009496
Purity≥98%
MDL No.MFCD02681897

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Benzothiophene-3-sulfonyl chloride|CS-W009496

Structure of 18494-87-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 18494-87-6
Cat. No. CS-W009496
Purity ≥98%
MDL No. MFCD02681897
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅ClO₂S₂
Molecular Weight 232.70
Synonym(s) 1-Benzothiophene-3-sulfonyl chloride
SMILES ClS(=O)(=O)C1=CSC2=CC=CC=C12

Description

Benzothiophene-3-sulfonyl chloride features a reactive sulfonyl chloride group flanked by an electron-rich benzothiophene core, enabling direct incorporation into sulfonamide derivatives. This bench-stable reagent facilitates efficient coupling under mild conditions, delivering high-yield functionalization in synthetic and medicinal chemistry workflows.

Application

Benzothiophene-3-sulfonyl chloride serves as a versatile acylating agent for the introduction of a benzothiophene-3-sulfonyl group into diverse molecular scaffolds. It enables efficient formation of sulfonamides and sulfonate esters under mild conditions, demonstrating good bench stability and compatibility with common functional groups. This reagent facilitates access to key intermediates in medicinal chemistry campaigns, particularly in kinase inhibitor and GPCR-targeted drug discovery, where the sulfonyl moiety contributes to target binding affinity and metabolic stability.

Synthesis

Route1
- 66225-23-8
- ~6%
- In-stock
  
  18494-87-6
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 14 p. 3844 - 3847

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 34.14
LogP 2.8288
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Benzothiophene compounds

Key Words

Benzothiophene-3-sulfonyl chloride sigmaBenzothiophene-3-sulfonyl chloride manufacturerBenzothiophene-3-sulfonyl chloride priceBenzothiophene-3-sulfonyl chloride structureBenzothiophene-3-sulfonyl chloride SDSbuy Benzothiophene-3-sulfonyl chlorideBenzothiophene-3-sulfonyl chloride supplierBenzothiophene-3-sulfonyl chloride usesBenzothiophene-3-sulfonyl chloride molecular weightprice of Benzothiophene-3-sulfonyl chlorideBenzothiophene-3-sulfonyl chloride chemical name formula of Benzothiophene-3-sulfonyl chloride

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Benzothiophene-3-sulfonyl chloride

CAS No. 18494-87-6

Recommended Products