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CS-W001157 4
Total: USD 88.00

Methyl 2,2,2-trimethoxyacetate

  • CAS No. 18370-95-1

  • Cat. No. CS-W005715
  • Purity≥95%
  • MDL No.MFCD09701200

*For research and further manufacturing use only, not for direct human use.

Methyl 2,2,2-trimethoxyacetate|CS-W005715

Structure of 18370-95-1

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General Information

  • CAS No. 18370-95-1
  • Cat. No. CS-W005715
  • Purity ≥95%
  • MDL No. MFCD09701200
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂O₅
  • Molecular Weight 164.16
  • Synonym(s) TRIMETHOXY-ACETIC ACID METHYL ESTER
  • SMILES COC(=O)C(OC)(OC)OC

Description

Methyl 2,2,2-trimethoxyacetate is a bench-stable, moisture-tolerant acylating agent featuring a highly electrophilic carbonyl center flanked by three methoxy groups. This trialkoxy substitution enhances reactivity in nucleophilic addition reactions, enabling efficient formation of α-alkoxy ketones and related intermediates under mild conditions.

Application

Methyl 2,2,2-trimethoxyacetate serves as a stable, bench-ready synthon for the introduction of the 2,2,2-trimethoxyethyl group in organic synthesis. Its electron-withdrawing trimethoxyacetyl moiety facilitates nucleophilic addition reactions and functions as a key building block in heterocycle construction and carbonyl equivalent transformations. The molecule exhibits excellent functional group tolerance and simplifies purification due to its low volatility and high stability under standard laboratory conditions.

Synthesis

  • Route1
    • null|null
      67-56-1
    • null|null
      17640-25-4
    • ~91%
    • In-stock
      Methyl 2,2,2-trimethoxyacetate|CS-W005715
      18370-95-1

    References

    • Park, Ji Hae; Lee, Bun Yeoul Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 4 p. 1064 - 1066
  • Route2
    • null|null
      17640-25-4
    • ~78%
    • In-stock
      Methyl 2,2,2-trimethoxyacetate|CS-W005715
      18370-95-1

    References

    • Kantlehner, Willi; Kapassakalidis, Joannis J.; Maier, Thomas Liebigs Annalen der Chemie, 1980 , # 9 p. 1448 - 1454
  • Route3
    • null|null
      1069-12-1
    • ~%
    • In-stock
      Methyl 2,2,2-trimethoxyacetate|CS-W005715
      18370-95-1
    • null|null
      28793-21-7
    • null|null
      616-38-6

    References

    • Canadian Journal of Chemistry, , vol. 66, p. 2234 - 2243

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.99
  • LogP   -0.2476
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

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