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CS-W001157 4
Total: USD 88.00

2,2-Dimethoxyacetic acid

  • CAS No. 73569-40-1

  • Cat. No. CS-0524002
  • Purity≥97%
  • MDL No.MFCD06203292

*For research and further manufacturing use only, not for direct human use.

2,2-Dimethoxyacetic acid|CS-0524002

Structure of 73569-40-1

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General Information

  • CAS No. 73569-40-1
  • Cat. No. CS-0524002
  • Purity ≥97%
  • MDL No. MFCD06203292
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈O₄
  • Molecular Weight 120.10
  • Synonym(s) Dimethoxyacetic acid
  • SMILES O=C(O)C(OC)OC

Description

2,2-Dimethoxyacetic acid offers a stable, moisture-tolerant platform for C–C bond formation in synthetic workflows. The geminal dimethoxy group enhances electrophilicity at the alpha-carbon, enabling efficient coupling reactions under mild conditions. This bench-stable derivative integrates readily into complex molecular architectures requiring controlled reactivity and high functional group tolerance.

Application

2,2-Dimethoxyacetic acid serves as a stable, bench-ready synthon for the introduction of α-oxoester functionality. Its dimethyl acetal group enables selective hydrolysis to generate reactive ketene intermediates under mild acidic conditions, facilitating efficient α-acylation or cycloaddition reactions. The compound exhibits excellent functional group tolerance and is readily purified by recrystallization, making it a practical building block in the synthesis of heterocyclic scaffolds and carbonyl-containing natural product analogs.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H335
Precautionary Statements : P260-P261-P264-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   -0.3101
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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